When Van Helsing's mysterious invention, the "Monsterfication Ray", goes haywire, Drac and his monster pals are all transformed into humans, and Johnny becomes a monster. In their new mismatched bodies, Drac, stripped of his powers, and an exuberant Johnny, loving life as a monster, must team up and race across the globe to find a cure before it's too late, and before they drive each other crazy. With help from Mavis and the hilariously human Drac Pack, the heat is on to find a way to switch...

A happily domesticated grizzly bear named Boog, has his perfect world turned upside down after he meets Elliot, a scrawny, fast-talking one-horned wild mule deer. They both end up stranded together in the woods during hunting season and it's up to the duo to rally all the other forest animals and turn the tables on the hunters.

Elliott incessantly parades proudly with his antlers, until unwise rock-jumping sees them crushed, and thus his new pride. Bride Giselle thinks Elliott has commitment anxiety when he rushes off to take the lead in the rescue of canine buddy Mr. Weenie, who is kidnapped by a poodle's gang of master-devoted pets determined to reconvert him. The feral gang has great trouble even penetrating the heavily guarded holiday resort where the brainwashing attempt is happening.